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Project

Cross-species applicability of high throughput screening assays for thyroid hormone disruption.

There is currently an urgent need for new screening approaches to identify thyroid hormone disrupting chemicals, both in ecotoxicology and human toxicology. Toxicity testing in the 21st century increasingly relies on high throughput animal-free assays screening chemicals for their interaction with biological targets. While the thyroid system is highly conserved across vertebrate classes, conservation of the chemical susceptibility of the components of the thyroid system (enzymes, receptors) remains to be investigated. In this project, we will compare the deiodinase (the enzyme responsible for thyroid hormone (de)activation) inhibition potential of a set of test chemicals across zebrafish, pig, rat and man. This information is essential to bridge the gap between ecotoxicology and human toxicology and support the exchange of information.
Date:1 Apr 2019 →  30 Mar 2020
Keywords:MULTI-SPECIES, ZEBRAFISH, PREDICITVE TOXICOLOGY, THYROID HORMONE
Disciplines:Animal morphology, anatomy and physiology, Endocrinology, Developmental biology