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Project

Developing ex-vivo cultures of animal and human explants for toxicity screening and efficacy testing of new drugs and nanomedical formulations

The overall aim of the present project lies in the development of optimal ex-vivo cultures of animal and human explants using precision cut tissue slice technology in order to deliver new optimized toxicity screening and efficacy testing tools for new drugs and nanomedical formulations. The explants will allow the student to explore the biology and pathology of the tissue of interest, mainly, the airways and parenchyma in respiratory diseases and lung tumors, and the brain tissue in glioblastoma. This will also aim to establish a 3 dimensional ex-vivo system that is closer to real human exposure and will lead to reducing the number of animals used in preclinical studies.

Date:1 Sep 2020 →  Today
Keywords:3D model, nanomedicine, PCTS
Disciplines:Histology, Toxicology and toxinology not elsewhere classified, General diagnostics, Microbial diagnostics, Molecular diagnostics, Protein diagnostics, Diagnostics not elsewhere classified
Project type:PhD project