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Project

Developing a novel combination of immunotherapy with induction of oxidative stress to treat solid tumors.

In this project we aim to develop a novel combination therapy to treat cancer that combines induction of oxidative stress with immune checkpoint inhibition. By this project, we will obtain insight in the underlying mechanisms of ionized gas for cancer treatment by doing in vitro and in vivo experiments. We will investigate the effects of both direct and indirect treatment on pancreatic cancer and melanoma cells, in terms of: 1) induction of reactive species, 2) selectivity towards cancer cells versus normal cells, 3) effect of hypoxia; and 4) immunogenicity. Next, we will test the therapeutic effect of the combination of oxidative stress with immune checkpoint inhibition.
Date:1 Oct 2019 →  30 Sep 2023
Keywords:CANCER THERAPY, IMMUNE CHECKPOINT INHIBITOR, REACTIVE OXYGEN SPECIES
Disciplines:Cancer therapy