Development of advanded fluorescence microscopy methods for studying the structure, the transport and stability of nanomedicines for gene therapy of the retinal pigment epithelium.

Several types of nanomecicines are evaluated for deliviry nucleic acids to retinal pigment epithilium (RPE) cells. However, more information is nedded on their stability and transport in biological media like the vitreous gel, retina and inside the RPE dells. In this project we will develop and apply several advanced fluorescence microscopy methods to increase our understanding of their physico chemical properties.