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Project

Ecology of foodborne pathogens

This research focuses on how foodborne pathogens experience and respond to their environment, and in particular the stresses and selection pressures they encounter throughout the food production chain. By elaborating analytical genetics and live cell biology approaches, stress response and adaptation phenomena of foodborne pathogens are dissected and studied from single-cell behaviour up to population level strategies. More specifically, this research is integrating:

(i) intracellular genetic regulation, expression, activity and whereabouts of genes, proteins and pathways involved in stress perception, response and repair

(ii) molecular/genetic principles underlying intercellular differentiation, and phenotypic consequences of the resulting population heterogeneity in isogenic populations

(iii) short-term adaptive evolution in clonal populations, understanding the physiological impact and repercussions of selected point mutations and chromosomal rearrangements, and mechanistic reconstruction of cellular resistance development

(iv) long-term ecological evolution, understanding cellular acquisition, domestication and impact of mobile genetic elements (such as prophages)

Date:1 Oct 2009 →  30 Sep 2019
Keywords:Microbial adaptation, Microbial genetics, Microbial cell biology, Foodborne pathogens, Microbial stress response
Disciplines:Food sciences and (bio)technology not elsewhere classified, Bacteriology, Genetics, Molecular and cell biology not elsewhere classified