Effects of High Intensity Interval Training versus Circuit Resistance Training on Endothelial Function and Peripheral Oxygen Extraction in Patients with Heart Failure: A Randomized Trial. (R-9898)

Exercise physical training is strongly recommended as a therapeutic approach to treat individuals with Heart Failure (HF), an extremely prevalent cardiovascular disease impacting on patient's life and society The present research proposal aims to verify the repercussion exercise training modalities high-intensity interval training (HIIT) and circuit resistance training (CRT) in HF. Findings of those modalities have already indicated improvements in HF status, mainly by increasing cardiorespiratory capacity. However, the mechanisms involved to increase functional capacity are not fully understood in the scientific literature, especially over endothelial function and oxygen peripheral extraction. Improvements in those outcomes can impact the quality of life and prognosis of HF individuals positively, by improving dyspnea and fatigue symptoms increasing exercise tolerance. In order to better understand the physiological pathways responsible for the benefits of HIIT and CRT physical training, we aim to explore the training repercussions over endothelial function (FE) and peripheral oxygen extraction. Improved EF and increased oxygen supply may result in improved vascular flow and peripheral oxygen extraction to peripheral musculature, justifying the benefits currently described in this population. Objective: To analyze and compare HIIT and CRT exercise modalities in endothelial function and peripheral oxygen extraction in patients with preserved and reduced HF. Methods: It is a multicenter randomized controlled trial, longitudinal and parallel involving patients with reduced and preserved HF, divided into HIIT, CRT and control groups (CG). Endothelial function and peripheral oxygen extraction evaluations will occur on pre and post moments following standard recommendations. We expect HIIT modality will promote better results by increasing endothelial function and muscular peripheral oxygenation. This hypothesis is based on constant exercise duration and higher intensity compared to CRT, potentially influencing higher vasodilatation effect and O2 peripheral extraction, as oxidative metabolism is mainly required to provide energy supply in this modality.

Keywords:Musculoskeletal research (human)

Disciplines:Cardiology, Organ physiology, Rehabilitation

Project type:Collaboration project