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Elucidating the role of Hexokinase 2 in physiology and disease.

Annually 2.8 million people die as consequences of obesity-associated disease, due to a lack of basic understanding of the disease and therefore an effective treatment. In response to sustained positive energy balance, fat cells store excess energy as lipids, leading to obesity. Obesity is associated with insensitivity to the glucose lowering hormone insulin and thus reduced glucose uptake into fat cells, a phenomenon termed insulin resistance. However, the molecular mechanism of obesity-associated insulin resistance is unclear. I will explore the molecular mechanism of insulin resistance using diet- and genetically induced mouse models and Mexican cavefish. Mexican cavefish are naturally resistant to insulin as an adaptation to surviving in nutrient-limited cave conditions. The proposed studies will provide insight on the complex nature of obesity and obesityassociated disorders such as diabetes and fatty liver disease.


Date:1 Oct 2020 →  Today
Keywords:adipose tissue, obesity, diabetes
Disciplines:Molecular physiology