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Project

Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalis

Non-coding variants in functional genomic regions such as cis-regulatory elements (CREs) may be implicated in missing heritability of inherited retinal diseases (IRDs). We aim to generate a regulatory map of the genome in retina and perform functional studies of (likely) pathogenic variants of CREs associated with IRD genes in Xenopus tropicalis using transgenic reporters and CRISPR/Cas9 genome editing.

Date:1 May 2022 →  30 Apr 2023
Keywords:Xenopus tropicalis, CRISPR/Cas9, cis-regulatory elements (CREs), non-coding genome, inherited retinal diseases (IRDs)
Disciplines:Ophthalmology, Animal genetics, Epigenetics, Genetics