Dendritic cells (DC) are the key players linking annate to adaptive immunity and the development o nanocarriers that can target and activate these cells while delivering an antien payload is believed to be o high importance in the development of the next generation of vaccines against intracellular pathogens and for the development of anti-cancer cavvines. here we aim to design nanovaccines based on gold nanoparticles with sezes ranging from 10-100 nm and decorated with antigen, DCC-targeting and DC-activating ligands.
Date:1 Mar 2013
30 Sep 2016
Keywords:gold nanoparicles, vaccines, dendritic cells
Disciplines:Industrial biotechnology, Pharmacognosy and phytochemistry, Toxicology and toxinology, Environmental engineering and biotechnology, Materials science and engineering, Other biotechnology, bio-engineering and biosystem engineering, Biomarker discovery and evaluation, Drug discovery and development, Biological system engineering, Biomaterials engineering, Medicinal products, Other pharmaceutical sciences, Biomechanical engineering, Pharmaceutics, Pharmacotherapy, Pharmacology, Other (bio)medical engineering, Semiconductor materials, Ceramic and glass materials, Other materials engineering