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Project
High-throughput DNA-methylation profiling of cardiovascular diseases
In light of the enormous impact of cardiovascular diseases (CVD) and clear indications for epigenetic effects, this project aims at the high-throughput identification of DNA-methylation markers involved in atherosclerosis, the principal cause of CVD. Herefore, a combination of ChIP, next-generation sequencing and high-throughput qPCR will be applied, supported by an apporopriate data-analysis, based on samples of the Asklepios study.
Date:1 May 2010 → 28 Feb 2013
Keywords:next-generation sequencing, atherosclerosis, epigenetics, DNA-methylation
Disciplines:Bioinformatics and computational biology, Medical biochemistry and metabolism, Scientific computing, Cardiac and vascular medicine, Public health care, Public health services, Biochemistry and metabolism