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Interleukin-34: an exciting new twist in the activation of the human Colony Stimulating Factor 1 Receptor (Interleukine-34)

We propose an interdisciplinary research project at the frontline of molecular structural biology to dissect the interaction of a novel cytokine, interleukin-34 (IL-34), with its hematopoietic receptor tyrosine kinase III (RTKIII) receptor, Colony Stimulating Factor-1 Receptor (CSF-1R of c-fms). The proposed research project aims to provide important new insights into the structural, kinetic and thermodynamic determinants that dicate this unusual cytokine-receptor specificty.

Date:1 Jan 2010 →  31 Dec 2015
Keywords:structural biology, protein-protein interaction, immune system, hematopoiesis
Disciplines:Immunology, Molecular and cell biology, Systems biology, Biophysics, Plant biology, Analysis, Medicinal and biomolecular chemistry