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Project

Mitochondrial abnormalities in critical illness: role in organ failure and mortality, underlying mechanisms and therapeutic perspectives.

Critically ill patients have a high risk of multiple organ failure and death. A disturbed cellular energy metabolism likely contributes to the organ system dysfunction, which is in fact the most common cause of death in intensive care units. The aims of this project are to thoroughly characterize the mitochondrial abnormalities in critical illness, to investigate the role of glucose toxicity in the development of these disturbances, and to study the mitochondrial compartment in relation to survival.
Date:1 Oct 2008 →  30 Sep 2009
Keywords:Insulin, Hyperglycemia, Mitochondria, Organ damage, Critical illness, Mortality
Disciplines:Anaesthesiology, Intensive care and emergency medicine, Endocrinology and metabolic diseases, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences