Molecular biology of the androgen receptor and its role in the development and homeostasis of skeletal muscle.

The gender differences in skeletal muscles are in a large part due to differences in sex steroids. Male hormones act by activating the androgen receptor, which is a transcription factor. Direct and indirect actions of the androgens will be studied at the molecular level to determine which signal transduction pathways are affected. This will be investigated by means of transgenic mouse models and in vitro cultures of skeletal muscle cells.

Keywords:Androgen receptor, Satllite cell, Frailty, Skeletal muscle, Myostatin

Disciplines:Endocrinology and metabolic diseases, Orthopaedics, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences