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Project

Molecular genetics of mantle cell lymphoma.

Mantle cell lymphoma (MCL) is a well-defined B-cell neoplasm with a poor prognosis and a short survival. MCL is hallmarked by t(11;14)(q13;q32) that leads to overexpression of cyclin D1, an important regulator of the G1 phase of the cell cycle. This tumor shows the high level of genomic instability, reflected by complex karyotypes and numerous non-recurrent secondary aberrations likely playing an important role in disease maintenance and progression. Genomic abnormalities in MCL have not been fully explored and targets of many secondary changes that could contribute to development and progression of MCL in concert with t(11;14) await identification. The proposed project aims at comprehensive analysis of a large series of MCL using the most recent cytogenetic modalities and high resolution genomic scanning platforms. We collected 300 cytogenetically documented MCL cases including 80 cases with 1-6 consecutive biopsies. Genome of these lymphomas will be profiled using the next generation genomic arrays able to detect submicroscopic genomic aberrations with the highest available resolution of 300-1000 bp. Studying in a genomic-wide fashion diagnostic and follow up MCL biopsies, we will search for new recurrent genomic aberrations and patterns, that are potentially important for disease development, disease classification, prognosis, evolution and responsiveness to therapy.
Date:1 Jan 2011 →  31 Dec 2014
Keywords:Genomic profiling, Cyclin D1, t(11, 14), Mantle cell lymphoma, Genomic imbalances, Array CGH, SNP array, Karyotype evolution
Disciplines:Laboratory medicine, Systems biology, Hematology, Genetics, Molecular and cell biology