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Project
Multi-omics data integration in the context of regulatory networks to decipher regulatory metabolites in complex diseases such as cancer and neuro-inflammatory disorders
First, we will conduct a benchmarking of computational methods for multi-omics data integration. Next, we will develop an improved methodology for multi-omics data integration in the context of regulatory networks to gain in-depth mechanistic insights. Finally, we will apply our methodology to neuro-inflammatory disorders and cancer to identify novel regulators such as regulatory metabolites.
Date:1 Nov 2020 → Today
Keywords:network inference, machine learning, metabolomics, dimensionality reduction, epigenomics, gene regulation, benchmarking, clustering, transcriptomics
Disciplines:Bioinformatics data integration and network biology