Multivalent dual-responsive polymeric nanoparticles for targeted anti-cancer therapy

In this project we aim to develop a formulation that selectively delivers anti-cancer drugs to cancer cells while minimizing unwanted toxicity to healthy tissue. For this purpose we will encapsulate hydrophobic anti-cancer agents in polymeric nanoparticles thate are engineered with (1) targeting ligands to selectively bind to cancer cells and (2) stimuli-responsive properties to release their drug payload only after cellular uptake.