NEURON II - Proteolytic remodeling of the extracellular matrix in aberrant synaptic plasticity underlying epilepsy evoked by traumatic brain injury (TBI Epilepsy).

In the present project we aim at testing a hypothesis that MMP-9 and uPA/uPAR contribute to circuitry remodeling during post-traumatic epileptogenesis. We focus on those two molecular systems, because there is a strong support for their involvement in other models of epileptogenesis, as well as the partners of this consortium have excellent tools and expertise to investigate these molecules.

Keywords:TRAUMATIC BRAIN INJURY, EPILEPTOGENESIS, NEUROLOGICAL DISORDERS

Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing

Project type:Collaboration project