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Project

New Concepts for the Prevention and Treatment of Malaria Pathology.

Malaria is a major global disease causing >200 million clinical cases and >600 000 deaths each year. Upon transmission by Anopheles mosquitoes and after a clinically silent liver stage, the parasite infects red blood cell and can cause life-threatening complications. These complications arise from immune evasion by the parasite, and inappropriate immune reactions may also contribute.

Our research focuses on the pathogenesis of these complications, thereby investigating the role of specific parasite factors (e.g. hemozoin, sequestration) and host factors (inflammatory processes, dysmetabolism). Furthermore, we also investigate disease tolerance and disease resolution. Disease tolerance comprises mechanisms to protect against severe disease without affecting parasite proliferation. Disease resolution encompasses the processes that mediate ending inflammation and stimulating repair and healing upon clearance of the parasite. Studying these tolerance and resolution mechanisms may therefore pave the way towards more successful therapies against severe malaria.

Date:1 Oct 2010 →  30 Sep 2020
Keywords:malaria, inflammation, immunity, metabolism, disease tolerance, disease resolution
Disciplines:Infectious diseases, Inflammation, Immunology not elsewhere classified, Parasitology, Tropical medicine