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Project

Noisy electrical stimulation of the brain, investigated in vitro through its synaptic, neuronal and microcircuitry correlates: a novel tool for basic research and neurological therapies.

We aim at investigating the cellular and electrophysiological correlates of noisy electrical stimulation of the nervous tissue, as in recent advances of Deep Brain Stimulation. By whole-cell patch-clamp and arrays of glass substrate microelectrodes, we will design a new paradigm for distributed extracellular stimulation in acute brain slices, replicating in vitro the irregular cortical firing of in vivo neurophysiology as well as mimicking the therapeutic stimulation protocols.
Date:1 Jul 2009 →  31 Dec 2013
Keywords:DEEP BRAIN STIMULATION, NEURONAL MICROCIRCUITS, NEURON POPULATIONS, ELECTRICAL STIMULATION
Disciplines:Systems biology, Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing