Onderzoek naar een evolutionair bewaard mechanisme van suikerdetectie en de novo lipogenese?.

Animals sense and adapt to fluctuating nutrient supplies to maintain metabolic homeostasis. In a sufficiently fed condition, organisms activate the signaling pathways and transcriptional programs to promote the storage of the excess energy, which is leveraged to sustain basal activities in a food-deprived state. In vertebrates, adipose tissue serves as the primary energy storage organ. In addition to acting as a reservoir for dietary lipids, adipose tissue senses sugar influx and promotes the conversion of sugar to lipids, a metabolic process termed de novo lipogenesis. However, our understanding of the sugar sensing mechanism in adipose tissue is far from complete. In this research proposal, I will elucidate the molecular mechanism of sugar sensing by investigating a signaling pathway controlling the transcriptional program of adipose tissue de novo lipogenesis. My findings will contribute to our understanding of nutrient sensing, metabolic adaptation, and thereby animal physiology.

Keywords:Adipose tissue, Metabolism, transcriptional regulation

Disciplines:Carbohydrates, Energy metabolism, Regulation of metabolism, Cell signalling, Posttranslational modifications