Optimizing Memory in Humans: Neurophysiological Modulation of Motor Memory Acquisition and Consolidation

Memory is a fundamental capacity that is intimately linked to our daily activities and underlies our identity, knowledge as well as our motor skills. Important discoveries over the last decades have greatly enhanced our understanding of the neural mechanisms supporting mnemonic processes. However, a critical question that has significant clinical and fundamental implications remains to be answered: “How can memory be optimized?” This intriguing question is the overarching motivation for the present research program. Accordingly, the aim of this project is to determine, using neuroimaging, factors that can enhance memory formation and consolidation - the process by which memories are strengthened - in humans. Specifically, we will investigate the effect of non-invasive brain stimulation, during and after learning, but also during post-learning sleep, on memory formation and retention. The ultimate goal of this project is to develop tools to not only optimize memory in young adults, but also to alleviate memory deficits observed during physiological aging. The motor system represents an ideal target for this research program because motor deficits that result from aging or neurological disorders profoundly alter quality of life. The anticipated outcome of this project will have great applications for promoting healthy aging and ultimately for developing new neurorehabilitative approaches for the recovery of motor functions after brain injuries or neurodegeneration.