< Back to previous page
Project
Prolyl oligopeptidase and prolyl oligopeptidase inhibitors in models of neurodegeneration.
The objective of this project is to investigate the interactions between prolyl oligopeptidase and relevant biomolecules, in vitro and in the cell. We envisage three lines of research: (1) the interaction with alpha-synuclein and the connection with Parkinson's disease, (2) the interaction with tubulin, intracellular transport and secretion, (3) co-localisation with other cytosolic peptidases and the connection with the aggresome.
Date:1 Oct 2009 → 31 Mar 2010
Keywords:ALPHA-SYNUCLEIN, AGGRESOME, PROTEASE INHIBITOR, PROLYLOLIGOPEPTIDASES
Disciplines:Biochemistry and metabolism, General biology, Plant biology, Systems biology, Medical biochemistry and metabolism