Rational design and synthesis of antagonists of the TSLP complex using chemo- and bioinformatics approaches.

TSLP (thymic stromal lymphopoietin) is a pro-inflammatoir cytokine produced by the epithelial cells. It binds to its receptor called TSLPR. This project aims at developing a number of novel inhibitors which block the complexation of TSLP and TSLPR, using bio- en chemo-informatic tools.

Keywords:MODEL SYSTEMS

Disciplines:Scientific computing, Inorganic chemistry, Organic chemistry, Theoretical and computational chemistry, Other chemical sciences, Biochemistry and metabolism, Bioinformatics and computational biology, Systems biology, Medical biochemistry and metabolism, Public health care, Public health services