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Project

Regeneration and remodeling of sensory innervation around dental implants treated with platelet-rich plasma.

Teeth missing and subsequent dental implant placement, which are commonly seen along with population aging, may consequently change oral motor behavior and impair natural biting function with excessive damage to original periodontal mechanoreceptors. On the other hand, platelet-rich plasma (PRP), as a promising autologous growth factor, is considered to be able to affect the healing of peripheral nerve fibres. To explore the response of peri-implant sensory nerve fibres to PRP, seventy-two titanium implants were installed in 12 mongrel dogs, the arrangement of implant recipient cites are all randomly selected at mandibular posterior area following one out of 3 protocols: high-concentration PRP, lowconcentration PRP and control group without any PRP. The specimens are evaluated from ultra-structure of nerve fibres to their molecular level. The expected results will demonstrate a chronological remodeling change in the bone-implant interfaces, reveal a stimulating effect of PRP on peri-implant sensory innervation when applied during the healing phase, and suggest an interdependent relationship between the development of peri-implant nerve fibres and three dimensional (3D) bone structures.

Date:1 Oct 2014 →  30 Sep 2017
Keywords:Dental implants
Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences