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Project
The role of afferent neurons in the pathogenesis of gastrointestinal postinflammatory motility and sensitivity disturbances.
The aim of this project is to study the effect of experimental rat colitis in the postinflammatory phase (remission) on the motility of the gastrointestinal tract and the sensitivity of afferent nerves innervating the colon. We will study the pathophysiology of the postinflammatory motility- and sensitivity disturbances by investigating the involvement of TRPV1 and P2X3 receptors, mast cells and serotonin-containing enterochromaffin cells.
Date:1 Jan 2009 → 31 Dec 2012
Keywords:AFFERENT NEURONS, GASTRO-INTESTINAL, GASTROENTEROLOGY
Disciplines:Gastro-enterology and hepatology, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences