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Project

The role of the extracellular matrix proteases MMP-9 and uPA in the development of posttraumatic epilepsy following traumatic brain injury.

We propose a novel hypothesis for the development of PTE with a central role for ECM modulating components MMP-9 and uPA. TBI results in blood-brain barrier disruption, hyperexcitability and primary damage triggering repair mechanisms such as modulation ofthe ECM by proteases MMP-9 and uPA. These alterations in ECM proteases MMP-9 and uPA, followed by brain inflammation, induce abnormal synaptic remodeling and epileptogenesis, ultimately leading to PTE.
Date:1 Oct 2013 →  30 Sep 2015
Keywords:TRAUMATIC BRAIN INJURY, EXTRACELLULAR MATRIX, EPILEPSY
Disciplines:Multimedia processing, Biological system engineering, Signal processing, Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Project type:Collaboration project