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Project

Study of the molecular mechanisms by which chronic intestinal inflammation affects stem cell function leading to epithelial inflammation and cancer development

Chronic inflammation contributes to tumor promotion and progression, and many of the tumor-promoting effects of inflammation depend on the activation of the transcription factor NF-κB. Interference with NF-κB signalling therefore represents a potential new therapeutic approach. Our project concerns the study of how NF-kB-dependent inflammation affects intestinal tissue physiology and can contribute to the development of intestinal cancer.

Date:1 Oct 2011 →  30 Sep 2017
Keywords:cancer, NF-kB, stem cell, intestine, inflammation
Disciplines:Gastro-enterology and hepatology, Immunology