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Project
Synthesis and evaluation of radioligands for PDE7 imaging in addiction animal model
Recently, the mechanism of action of phosphodiesterase 7 (PDE7) inhibitors to fight addiction in humans waselucidated. In the literature, there are no radiotracers for PDE7 imaging. At UAMC, we synthesized 8 potentPDE7 inhibitors. The most potent compounds will be labeled with 11C and evaluated in vivo to determine if theyare suitable to quantify PDE7 in the brain and also injected in an addiction rat model.
Date:1 Feb 2015 → 31 Dec 2015
Keywords:PET SCAN, PDE7, RADIOTRACER, ADDICTION
Disciplines:Medical imaging and therapy, Medicinal products