Unraveling the 17q enigma in neuroblastoma: from functional genomics to molecular therapy

Neuroblastoma is a pediatric tumor of the peripheral nervous system. In this study we aim to investigate the role of 17q gain in the oncogenesis of this tumour through (1) the study of integrated genomics of NB, medulloblastoma, tumour initiating cells and normal precursor cells, (2) functional identification of oncogenic 17q miRNAs, (3) analysis of the NB 17q mutome and (4) analysis of chromosome 17 candidate NB genes.