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Project
Unraveling the molecular architecture of peripheral nerves- a system genetics approach.
This proposal aims to generate a more complete understanding of the molecular architecture of peripheral nerves by unraveling the molecular basis of Charcot-Marie-Tooth disease. We will use "omics" technologies to study patients and model organisms (yeast, Drosophila, mouse), focusing on the identification of causative and modifier CMT genes and the regulatory networks which they are involved in. Armed with this library of data, we will provide cues to the mechanistic and systems basis of peripheral nerve homeostasis and dysfunction.
Date:1 Jan 2014 → 31 Dec 2017
Keywords:GENE IDENTIFICATION, SYSTEMS GENETICS, MODEL ORGANISMS, PERIPHERAL NERVES
Disciplines:Genetics, Systems biology, Molecular and cell biology, Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing