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Project

Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID).

Common variable immunodeficiency disorder (CVID) is a group of diseases charachterized by a decrease in immunoglobulines and in number and/or function of B-lymphocyte subsets. Its heterogeneity complicates the elucidation of underlying disease mechanisms and gene defects.

This study aims to develop a classification of CVID patients integrating clinical data, immunophenotyping, molecular analyses and next-generation sequencing, in order to discover(new)gene defects.



Date:1 Oct 2013 →  30 Sep 2017
Keywords:genetic, classification, Common variable immunodeficiency disorder (CVID)
Disciplines:Immunology, Other clinical sciences, Laboratory medicine, Other health sciences, Other basic sciences, Regenerative medicine, Other medical and health sciences, Palliative care and end-of-life care, Nursing, Other paramedical sciences, Other translational sciences