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Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

Journal Contribution - Journal Article

BACKGROUND: Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The objective of the study was to assess whether CDA treatment and G6PD deficiency are risk factors for a post-treatment haemoglobin drop in African children
Journal: Malaria Journal
ISSN: 1475-2875
Issue: 139
Volume: 11
Pages: 1-7
Publication year:2012
Keywords:Protozoal diseases, Malaria, Plasmodium falciparum, Vectors, Mosquitoes, Anopheles, Treatment, Artemisinin combination therapies (ACT), Chlorproguanil, Dapsone, Artesunate, Children, Hemoglobin, Risk factors, G6PD deficiency, Randomized clinical trials, Africa-General, Author, PDF
Accessibility:Open