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Patient- and physician-level determinants of blood pressure response to treatment in normal weight and overweight patients (the PREVIEW study)
Journal Contribution - Journal Article
Background and aims: Obesity combined with hypertension places patients at greater risk for target-organ damage and cardiovascular disease. The purpose of this secondary analysis was to identify physician-and patient-levels determinants of blood pressure (BP) values and predictors of uncontrolled BP through subgroup analysis by body mass index (BMI).
Methods and results: We conducted a subgroup analysis of 3006 patients with High-BMI (BMI >25 kg/m(2); n = 2124) and Normal-BMI (BMI
Blood pressure values and control after 90 days of treatment were consistently lower for the High-BMI group. The 25.5% of variance in 90-day systolic and 28.3% of the variance in 90-day diastolic BP were attributable to physician-level determinants for the High-BMI group; versus 27.3% and 29.8% for the Normal-BMI group (ICC = 0.273 and 0.298, respectively). Determinants of 90-day BP values and predictors of uncontrolled BP varied considerably by BMI status.
Conclusion: Several common and unique patient- and physician-level determinants of BP values and control were identified for the High-BMI and Normal-BMI groups. These findings highlight the need for differentiating healthcare interventions to account for patient and physician variables, particularly with respect to effective BP management in vulnerable populations. (C) 2011 Elsevier B.V. All rights reserved.
Methods and results: We conducted a subgroup analysis of 3006 patients with High-BMI (BMI >25 kg/m(2); n = 2124) and Normal-BMI (BMI
Blood pressure values and control after 90 days of treatment were consistently lower for the High-BMI group. The 25.5% of variance in 90-day systolic and 28.3% of the variance in 90-day diastolic BP were attributable to physician-level determinants for the High-BMI group; versus 27.3% and 29.8% for the Normal-BMI group (ICC = 0.273 and 0.298, respectively). Determinants of 90-day BP values and predictors of uncontrolled BP varied considerably by BMI status.
Conclusion: Several common and unique patient- and physician-level determinants of BP values and control were identified for the High-BMI and Normal-BMI groups. These findings highlight the need for differentiating healthcare interventions to account for patient and physician variables, particularly with respect to effective BP management in vulnerable populations. (C) 2011 Elsevier B.V. All rights reserved.
Journal: Nutrition, Metabolism, and Cardiovascular Diseases [=NMCD]
ISSN: 0939-4753
Volume: 23
Pages: 314-322
Publication year:2013
Keywords:Hypertension, Obesity, Angiotensin 2 receptor blocker, Valsartan, Effectiveness, Body mass index, Pharmacoepidemiology