Researcher
Arthur Van Aerschot
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2022
Projects
11 - 19 of 19
- Development of new antibiotics: Synthesis of innovative aminoacylated sulfonamide nucleosides and mupirocin analogues as aminoacyl-tRNA-synthetase inhibitorsFrom1 Sep 2015 → 30 Sep 2020Funding: FWO fellowships
- Rational design of tRNA synthetase inhibitors as new antibacterials.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- The search for new antibiotics: evaluation of inhibitory ligands of tRNA synthetases based on a nucleoside scaffoldFrom16 Sep 2014 → 2 Jul 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Rational design of tRNA synthetase inhibitors as new antibacterials.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- Oligonucleotides as biochemical and therapeutic tools.From1 Jan 2011 → 31 Dec 2014Funding: FWO research project
- Liquid chromatogram couples to a mass spectrometer for bioanalytical applications.From22 Jul 2010 → 22 Jan 2017Funding: Hercules - Small and Medium size research infrastructure
- Nucleotides, nucleic acids and their analogues as tools or targets for inhibitor design.From1 Oct 2009 → 30 Sep 2014Funding: BOF - Concerted Research Project from 1994
- The bacterial protein quality control system as potential target for new antibacterial strategies.From1 Oct 2009 → 10 Sep 2015Funding: IWT personal funding - strategic basic research grants
- Synthesis and evaluation of microcin C analogs as aminoacyl-tRNA synthetase inhibitors.From1 Oct 2008 → 31 Dec 2012Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
Publications
1 - 10 of 98
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors(2023)
Authors: Stijn Lenders, Peter Verwilst, Sergei Strelkov, Arthur Van Aerschot
- Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides(2022)
Authors: Stijn Lenders, Evgenii Osipov, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip(2022)
Authors: Sergei Strelkov, Arthur Van Aerschot
- Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors(2022)
Authors: Evgenii Osipov, Arthur Van Aerschot, Sergei Strelkov
- Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies(2021)
Authors: Luping Pang, Sergei Strelkov, Arthur Van Aerschot
- Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.(2021)
Authors: Luping Pang, Arthur Van Aerschot
- Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors(2021)
Authors: Dries De Ruysscher, Luping Pang, Stijn Lenders, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors(2020)
Authors: Luping Pang, Steff De Graef, Eveline Lescrinier, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies(2020)
Authors: Luping Pang, Arthur Van Aerschot, Sergei Strelkov, Stephen Weeks
- Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase(2020)
Authors: Luping Pang, Steff De Graef, Sergei Strelkov, Arthur Van Aerschot