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- Research interest:1) CORE The Center for Oncological Research (CORE) has research expertise in personalized cancer medicine, with emphasis on 1) developing novel and more effective therapeutic strategies; 2) an improved detection and understanding of mechanisms driving therapeutic resistance; and 3) identifying and validating biomarkers for personalized therapy, in different cancers in need for improved therapeutic outcomes. Novel and emerging anticancer strategies that we investigate are targeted therapy, immunotherapy, radiotherapy, cold atmospheric plasma therapy as well as novel combination therapies. In CORE, there is a strong interdisciplinary collaboration between basic, translational and clinical researchers. The members of our consortium bring together unrivaled access to biobank patient samples and to a dedicated oncological clinical phase I/II unit with a unique and complementary set of methods and skills covering the entire spectrum of molecular techniques, 2D and 3D cellular assays (in vitro and ex vivo), animal studies and clinical studies. CORE gathers experts with an excellent research track record in targeted therapy, immunotherapy, radiotherapy, combination therapies, genomics, transcriptomics, proteomics, bioinformatics, liquid biopsies, pathology and clinical studies. 2) Personal expertise: - Fundamental and translational cancer research- Cell death mechanism (apoptosis, ferroptosis and immunogenic cell death)- The p53 protein and the biological implications of mutant p53- Oxidative stress as a therapeutic target for the treatment cancer- Focus on lung cancer and pancreatic cancer- Targeted therapies with the focus on drug repurposing- Immunotherapy - Combination strategies: conventional/targeted; conventional/immunotherapy; targeted/immunotherapy- Primary cancer organoids (lung and pancreas) - Prognostic and predictive biomarker studies- The role of a hypoxic tumor microenvironment on therapy respons- Cold-atmospheric plasma for the treatment of cancer- In vivo syngeneic mouse models for lung cancer
- Keywords:ONCOLOGY, IN VITRO MODEL, OXIDATIVE STRESS, LUNG CANCER, CELL DEATH, Biomedical sciences (incl. biochemistry)
- Disciplines:Innate immunity, Cell death , Cell signalling, Cancer biology, Cancer therapy , Biomarker discovery, Biomarker evaluation, In vitro testing
- Research techniques:Primary organoid cultures, 3D models, cytotoxicity screens, western blot, flowcytometry, live-cell imaging using a broad range of fluorescent markers (cell death, apoptosis, ROS, senescence, hypoxia,...) on the IncuCyteZOOM, hypoxic chamber, luminescence-based assays.
- Users of research expertise:biomedical research groups, cancer researchers