< Back to previous page
Researcher
Christophe Pannecouque
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
Publications
11 - 20 of 399
- Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Comprehensive study of alkaloids from Scadoxus multiflorus by HPLC-PDA-SPE-NMR and evaluation of their anti-SARS-CoV-2 activity(2023)
Authors: Steven De Jonghe, Johan Neyts, Christophe Pannecouque
Pages: 156 - 162 - Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 1272 - 1295 - Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 3054 - 3066 - Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 2747 - 2764 - Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 8643 - 8665 - Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 4755 - 4767 - Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S =O to CHOR(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Patents
1 - 7 of 7
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral activity of novel bicyclic heterocycles (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)