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Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
11 - 20 of 156
- Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation(2023)
Authors: Dirk Daelemans
- E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1(2023)
Authors: Bert Kwanten, Dirk Daelemans
- CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity(2023)
Authors: Wenting Guo, Elke Braems, Pegah Masrori, Evelien Van Schoor, Maarten Jacquemyn, Sriram Balusu, Tine Tricot, Pieter Vanden Berghe, Dietmar Thal, Rik Vandenberghe, et al.
Pages: 1245 - 1259 - CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids(2023)
Authors: Hui Yang, Mikhail Abramov, Maarten Jacquemyn, Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1501 - 1511 - Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines(2023)
Authors: Dirk Daelemans
- Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation(2022)
Authors: Tim Dierckx, Evelien Vanderlinden, Dominique Schols, Dirk Daelemans, Jurgen Vercauteren, Johan Van Weyenbergh
- Imidazo[4,5-b]pyridine derived tubulin polymerization inhibitors: Design, synthesis, biological activity in vitro and computational analysis(2022)
Authors: Dirk Daelemans
- Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity(2022)
Authors: Dirk Daelemans, Dominique Schols
Pages: 2595 - 2612 - The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems(2022)
Authors: Maarten Jacquemyn, Dirk Daelemans
- Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity(2022)
Authors: Dirk Daelemans
Pages: 1339 - 1350