Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
111 - 120 of 156
- Antiviral drug development against the influenza virus PA endonuclease:tackling a multifaceted challenge.(2015)
Authors: Annelies Stevaert, Lieve Naesens, Dirk Daelemans
- Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors(2015)
Authors: Erik De Clercq, Dirk Daelemans, Christophe Pannecouque
Pages: 1 - 9 - Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors(2015)
Authors: Zheng-Yong Wan, Jin Yao, Yuan Tao, Tian-Qi Mao, Xin-Long Wang, Yi-Pei Lu, Hai-Feng Wang, Hong Yin, Yan Wu, Fen-Er Chen, et al.
Pages: 1 - 9 - Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs(2015)
Authors: Denis A Babkov, Vladimir T Valuev-Elliston, Maria P Paramonova, Alexander A Ozerov, Alexander V Ivanov, Alexander O Chizhov, Anastasia L Khandazhinskaya, Sergey N Kochetkov, Jan Balzarini, Dirk Daelemans, et al.
Pages: 1069 - 1081 - Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs(2015)
Authors: Jan Balzarini, Dirk Daelemans, Christophe Pannecouque
Pages: 1069 - 1081 - Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase(2015)
Authors: Christophe Pannecouque, Erik De Clercq, Dirk Daelemans
Pages: 624 - 31 - Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase(2015)
Authors: Hai-Qiu Wu, Jin Yao, Qiu-Qin He, Wen-Xue Chen, Fen-Er Chen, Christophe Pannecouque, Erik De Clercq, Dirk Daelemans
Pages: 624 - 31 - Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing(2015)
Authors: Jasper Neggers, Thomas Vercruysse, Maarten Jacquemyn, Els Vanstreels, Erkan Baloglu, Sharon Shacham, Marsha Crochiere, Yosef Landesman, Dirk Daelemans
Pages: 107 - 116 - Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing(2015)
Authors: Jasper Neggers, Thomas Vercruysse, Maarten Jacquemyn, Els Vanstreels, Dirk Daelemans
Pages: 107 - 116 - Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19(2014)
Authors: Dirk Daelemans, Christophe Pannecouque
Pages: 3248 - 58