Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
121 - 130 of 156
- A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity(2014)
Authors: Eline Boons, Guangdi Li, Els Vanstreels, Thomas Vercruysse, Christophe Pannecouque, Anne-Mieke Vandamme, Dirk Daelemans
Pages: 91 - 102 - Identification of different phenotypes of interstitial cells in the upper and deep lamina propria of the human bladder dome(2014)
Authors: Thomas Gevaert, Els Vanstreels, Dirk Daelemans, Jan Franken, Frank Van der Aa, Tania Roskams, Dirk De Ridder
Pages: 1555 - 1563 - Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands(2014)
Authors: Dirk Daelemans, Christophe Pannecouque
Pages: 4658 - 4666 - Dynamics of the Ternary Complex Formed by c-Myc Interactor JPO2, Transcriptional Co- activator LEDGF/p75, and Chromatin(2014)
Authors: Jelle Hendrix, Els Vanstreels, Dirk Daelemans, Jan De Rijck
Pages: 12494 - 12506 - Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase(2014)
Authors: Christophe Pannecouque, Jan Balzarini, Dirk Daelemans, Erik De Clercq
Pages: 468 - 473 - HIV-1 Rev multimerization: mechanism and insights(2013)
Authors: Thomas Vercruysse, Dirk Daelemans
Pages: 623 - 34 - Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies(2013)
Authors: Erik De Clercq, Jan Balzarini, Dirk Daelemans, Christophe Pannecouque
Pages: 6477 - 6483 - Role of PFKFB3-Driven Glycolysis in Vessel Sprouting(2013)
Authors: Katrien De Bock, Sandra Schoors, Anna Kuchnio, Brian Wong, Anna Rita Cantelmo, Annelies Quaegebeur, Bart Ghesquière, Guy Eelen, Ilse Geudens, Bert Cruys, et al.
Pages: 651 - 663 - Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors(2013)
Authors: Christophe Pannecouque, Dirk Daelemans, Yang Liu, Erik De Clercq
Pages: 134 - 143 - Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome(2013)
Authors: Katrien Deroost, Sam Noppen, Els Vanstreels, MIna Komuta, Tania Roskams, Dirk Daelemans, Ghislain Opdenakker, Philippe Van den Steen
Pages: 589 - 600