Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
41 - 50 of 155
- enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9(2021)
Authors: Maarten Jacquemyn, Tim Dierckx, Hendrik Jan Thibaut, Dirk Daelemans
Pages: 208 - 224 - Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity(2021)
Authors: Dirk Daelemans, Erik De Clercq, Christophe Pannecouque
Pages: 67 - 76 - Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles(2021)
Authors: Dirk Daelemans, Dominique Schols
- Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity(2020)
Authors: Dirk Daelemans, Steven De Jonghe
Pages: 2477 - 2490 - Design, synthesis and biological evaluation of pyrazolo[3,4-d] pyrimidine-based protein kinase D inhibitors(2020)
Authors: Philippe Gilles, Rudra Shankar Kashyap, Steven De Jonghe, Dirk Daelemans, Johan Van Lint, Arnout Voet, Wim De Borggraeve
- Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials(2020)
Authors: Thijs Van Leemputte, Xabier Villanueva, Dirk Daelemans, Hans Steenackers
Pages: 2864 - 2878 - Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I-2 Receptor Ligands for Alzheimer's Disease (vol 63, pg 3610, 2020)(2020)
Authors: Sonia Abas, Sergio Rodriguez-Arevalo, Andrea Bagan, Christian Grinan-Ferre, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belen Perez, Elies Molins, F Javier Luque, et al.
Pages: 10529 - 10529 - Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7(2020)
Authors: Dirk Daelemans, Erik De Clercq, Christophe Pannecouque
- Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides(2020)
Authors: Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1605 - 1610 - Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration(2020)
Authors: Thomas Vercruysse, Philip Van Damme, Ludo Van Den Bosch, Dirk Daelemans