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Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 29
- Validation of CCR8 agonism as therapeutic strategy for treatment of (auto-)inflammationFrom1 Mar 2024 → TodayFunding: IOF - technology validation in lab
- Real-time, label-free analysis of extracellular vesicles and their proteins using surface plasmon resonance technologyFrom29 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The viral G protein-coupled receptor ORF74: Expanding the toolbox to better understand receptor signaling, function and pharmacologyFrom22 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Elucidation of the mechanism of action of novel HTLV-1 inhibitors: a step-by-step approachFrom21 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development and preclinical evaluation of diagnostic and therapeutic radiopharmaceuticals targeting CXCR4From10 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signallingFrom1 May 2021 → TodayFunding: BOF - doctoral mandates
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Design and synthesis of next-generation C-C chemokine receptor type 5 antagonists.From28 Jul 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Discovery of CCR7 small molecule inhibitors by virtual screening andhit-to-lead optimization.From1 Oct 2019 → 30 Sep 2021Funding: BOF - projects
Publications
1 - 10 of 370
- Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.(2024)
Authors: Dominique Schols, Steven De Jonghe
Pages: 107181 - trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors.(2024)
Authors: Tom Van Loy, Dominique Schols
Pages: 5616 - 5623 - Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds(2024)
Authors: Dominique Schols
- Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives(2024)
Authors: Dominique Schols
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity(2024)
Authors: Sam Noppen, Mieke Gouwy, Lisa Verhallen, Mirre De Bondt, Dominique Schols, Pedro Elias Marques, Sofie Struyf, Paul Proost
- Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Membrane-permeable tenofovir-di- and monophosphate analogues(2024)
Authors: Dominique Schols
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities(2023)
Authors: Dominique Schols, Steven De Jonghe
Patents
1 - 6 of 6
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)