Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 29
- Validation of CCR8 agonism as therapeutic strategy for treatment of (auto-)inflammationFrom1 Mar 2024 → TodayFunding: IOF - technology validation in lab
- Real-time, label-free analysis of extracellular vesicles and their proteins using surface plasmon resonance technologyFrom29 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The viral G protein-coupled receptor ORF74: Expanding the toolbox to better understand receptor signaling, function and pharmacologyFrom22 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Elucidation of the mechanism of action of novel HTLV-1 inhibitors: a step-by-step approachFrom21 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development and preclinical evaluation of diagnostic and therapeutic radiopharmaceuticals targeting CXCR4From10 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signallingFrom1 May 2021 → TodayFunding: BOF - doctoral mandates
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Design and synthesis of next-generation C-C chemokine receptor type 5 antagonists.From28 Jul 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Discovery of CCR7 small molecule inhibitors by virtual screening andhit-to-lead optimization.From1 Oct 2019 → 30 Sep 2021Funding: BOF - projects
Publications
31 - 40 of 370
- Visible-Light-Promoted Tandem Thiol-Ene Click Reaction/Transannular Cyclization and Regioselective Cyclopropane Ring- Opening to Construct Sulfur-Containing Euphorbia Diterpenes(2023)
Authors: Steven De Jonghe, Dominique Schols
- Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates(2023)
Authors: Rana Abdelnabi, Dominique Schols, Johan Neyts
- Design and synthesis of a new series of hybrids of functionalised N 1-[(1H-1,2,3-triazol- 4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus(2023)
Authors: Robert Snoeck, Emiel Vanhulle, Mirthe Graus, Graciela Andrei, Dominique Schols, Kurt Vermeire
- Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections(2023)
Authors: Dominique Schols
Pages: 99 - 115 - Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors(2023)
Authors: Hongtao Xu, Merel Oeyen, Steven De Jonghe, Dirk Jochmans, Johan Neyts, Piet Herdewyn, Dominique Schols
- Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation(2022)
Authors: Tim Dierckx, Evelien Vanderlinden, Dominique Schols, Dirk Daelemans, Jurgen Vercauteren, Johan Van Weyenbergh
- Can we attenuate ischaemia-reperfusion injury of allografts in a porcine left lung transplant models by adsorption of cytokines?(2022)
Authors: Arno Vanstapel, Dominique Schols, Laurens Ceulemans, Robin Vos, Geert Verleden, Bart Vanaudenaerde, Stijn Verleden, Dirk Van Raemdonck, Arne Neyrinck
- Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents(2022)
Authors: Mirthe Graus, Emiel Vanhulle, Johan Neyts, Dominique Schols, Kurt Vermeire, Steven De Jonghe
- Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones(2022)
Authors: Graciela Andrei, Dominique Schols, Robert Snoeck
- Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity(2022)
Authors: Dirk Daelemans, Dominique Schols
Pages: 2595 - 2612
Patents
1 - 6 of 6
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)