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Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
11 - 20 of 29
- Development and evaluation of new classes of CXCR2 antagonists with applications in inflammation and infectionFrom3 Sep 2019 → 3 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- A basic research pipeline for discovery and early preclinical development of host-targeted antiviral strategies to combat encephalitic alphavirusesFrom19 Jul 2018 → 30 Nov 2021Funding: Foreign public sponsor
- Establishment of in vitro assays for the discovery of GPCR small molecule ligandsFrom30 May 2018 → 30 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of novel chemokine receptor inhibitors for anti-cancer therapyFrom1 Oct 2017 → 30 Sep 2019Funding: Fund Recuperation Fiscal Exemption, BOF - Concerted Research Project from 1994
- Entry inhibitors for human respiratory virus SARS-CoV-2.From21 Aug 2017 → 6 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development of a technology platform for next-generation cytometryFrom1 Jul 2016 → 30 Jun 2020Funding: FWO Large scale research infrastructure
- Immunosuppressive effects of a CD4 receptor down-modulator: in vitro study of the signal peptide-dependent ER translocation inhibitor cyclotriazadisulfonamide (CADA)From1 Oct 2014 → 26 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- Characterisation of novel CXCR4-targeting nanobodies with anti-HIV and anti-tumoral activityFrom1 Sep 2014 → 10 Oct 2019Funding: BOF - Doctoral projects
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Study of a signal peptide-specific translocation inhibitor: a unique down-modulator of CD4From1 Oct 2012 → 22 Sep 2017Funding: BOF - Doctoral projects
Publications
1 - 10 of 370
- Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.(2024)
Authors: Dominique Schols, Steven De Jonghe
Pages: 107181 - trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors.(2024)
Authors: Tom Van Loy, Dominique Schols
Pages: 5616 - 5623 - Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds(2024)
Authors: Dominique Schols
- Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives(2024)
Authors: Dominique Schols
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity(2024)
Authors: Sam Noppen, Mieke Gouwy, Lisa Verhallen, Mirre De Bondt, Dominique Schols, Pedro Elias Marques, Sofie Struyf, Paul Proost
- Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Membrane-permeable tenofovir-di- and monophosphate analogues(2024)
Authors: Dominique Schols
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities(2023)
Authors: Dominique Schols, Steven De Jonghe
Patents
1 - 6 of 6
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)