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Researcher
Elisabetta Groaz
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Apr 2007 → Today
Projects
1 - 10 of 10
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backboneFrom10 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo-type phosphonate nucleic acids: synthesis and structure analysisFrom17 Sep 2018 → 30 May 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of C-nucleoside analoguesFrom25 Sep 2015 → 23 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENINGFrom15 Jun 2014 → 7 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic SelectionFrom1 Sep 2013 → 31 Oct 2021Funding: SCK (Study Centre Nuclear Energy)
Publications
1 - 10 of 54
- Impact of sulfur substitution on biotin binding affinity to streptavidin.(2024)
Authors: Elisabetta Groaz, Piet Herdewyn
Pages: 107600 - Impact of Single Acyclic Phosphonate Nucleotide (ZNA) Modifications on DNA Duplex Stability(2024)
Authors: Elisabetta Groaz, Piet Herdewyn, Eveline Lescrinier
- Xylo-type phosphonate nucleic acids: synthesis and structure analysis(2024)
Authors: Yuqing Xu, Eveline Lescrinier, Piet Herdewyn, Elisabetta Groaz
- Rational design of a bacterial import system for new-to-nature molecules.(2024)
Authors: Elisabetta Groaz, Piet Herdewyn
Pages: 26 - 34 - Modulation of the tetrameric I-motif folding of C-rich Tetrahymena telomeric sequences by hexitol nucleic acid (HNA) modifications(2023)
Authors: Piet Herdewyn, Elisabetta Groaz
Pages: 112 - 122 - Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties(2023)
Authors: Elisabetta Groaz, Jef Rozenski
- Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymer(2023)
Authors: Elisabetta Groaz
Number of pages: 34 - Synthesis, antiviral activity, and computational study of β-D-xylofuranosyl nucleoside phosphonates(2023)
Authors: Yuqing Xu, Elisabetta Groaz, Jérôme Rihon, Piet Herdewyn, Eveline Lescrinier
- CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids(2023)
Authors: Hui Yang, Mikhail Abramov, Maarten Jacquemyn, Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1501 - 1511 - O-2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus(2022)
Authors: Elisabetta Groaz, Piet Herdewyn
Patents
1 - 7 of 7
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)