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Researcher
Els Henckaerts
- Disciplines:Virology, Molecular and cell biology not elsewhere classified, Neurological and neuromuscular diseases
Affiliations
- Trellis Research Group (Division)
Responsible
From1 Oct 2019 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2019 → Today - Trellis Research Group (Division)
Member
From1 Oct 2019 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From1 Aug 2019 → 30 Sep 2019
Projects
1 - 10 of 12
- Validation and standardisation of analytics in downstream bioprocessing of rAAV vectors.From10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of an ultra-efficient dual AAV gene therapy congenital deafness.From1 Oct 2023 → TodayFunding: IOF - mandates
- Improving specificity in gene therapy through nanobody coupling of AAV vectors.From1 Jan 2023 → 31 Dec 2023Funding: IOF - technology validation in lab
- Characterization of the replication-encapsidation link in AAV to maximize the vector production efficiency for gene therapyFrom11 Oct 2022 → 4 Aug 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- A biology-driven approach to tackle challenges in AAV gene therapyFrom4 Aug 2021 → 21 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Novel platforms for studying AAV subcellular biology & the design of improved gene therapy vectorsFrom1 Oct 2020 → TodayFunding: BOF - doctoral mandates
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- A European translational engine for AAV gene therapy.From1 Feb 2020 → TodayFunding: Department Coordination
- Determination of the role of SF3B1 in the regulation of the adeno-associated virus life cycle.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Characterization of the adeno-associated virus Rep interactomeFrom19 Dec 2019 → 30 Sep 2021Funding: IOF - technology concept exploration
Publications
1 - 8 of 8
- Rational evolution for altering the ligand preference of estrogen receptor alpha(2024)
Authors: Xiao Yin Lee, Karin Voordeckers, Els Henckaerts, Vitor Bernardes Pinheiro, Frank Claessens, Kevin Verstrepen, Arnout Voet, Christine Helsen
- Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC(2023)
Authors: Els Henckaerts
- A novel Adeno-associated viral gene therapy treatment protocol in sheep for use in MPSIIIC and other neurological disorders(2022)
Authors: Els Henckaerts
Pages: A76 - A77 - Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2(2021)
Authors: Els Henckaerts
- Herpes Simplex Virus 1 Coinfection Modifies Adeno-associated Virus Genome End Recombination(2021)
Authors: Els Henckaerts
- The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states(2020)
Authors: Bram Vandewinkel, Els Henckaerts
Pages: 12983 - 12999 - Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors(2020)
Authors: Els Henckaerts
- Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome(2018)
Authors: Mathieu Bollen, Els Henckaerts
Pages: E3529 - E3538