Researcher
Frank Claessens
- Disciplines:Endocrinology, Structural biology, Molecular and cell biology not elsewhere classified, Cancer biology, Urology and nephrology not elsewhere classified
Affiliations
- Laboratory of Molecular Endocrinology (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Molecular Endocrinology (Division)
Member
From1 Oct 2007 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2000 → 31 Dec 2002
Projects
1 - 10 of 36
- Free steroid hormones in health and disease (FRESH-HD)From23 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Cooperativity between the androgen receptor and forkhead box A1 transcription factorFrom7 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- New therapeutic targets in the dimerization modes that drive androgen receptor functioningFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- New therapeutic targets in the dimerization modes that drive androgen receptor functioningFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Peroxisomes and the Malignant Potential of Prostate Cancer Cells.From17 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- TISSUE-SPECIFIC MODULATION OF GLUCOCORTICOID EFFECTS BY ANDROGENSFrom26 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tissue specific modulation of the effects of glucocorticoids by androgens and the androgen receptor: revealing the mechanisms of cross talFrom1 Oct 2020 → TodayFunding: BOF - doctoral mandates
- Classical and non-classical actions of androgens and their receptorFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- The role of androgens in chronic kidney desease: a missing link in the calcification paradox?From1 Aug 2019 → 31 Oct 2023Funding: FWO fellowships
- Structural Biology of the Human Androgen Receptor for next generation drug designFrom12 Mar 2018 → 12 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 222
- Re: Abiraterone and Olaparib for Metastatic Castration-resistant Prostate Cancer.(2024)
Authors: Alexander Giesen, Frank Claessens, Steven Joniau
Pages: 396 - Rational evolution for altering the ligand preference of estrogen receptor alpha(2024)
Authors: Xiao Yin Lee, Karin Voordeckers, Els Henckaerts, Vitor Bernardes Pinheiro, Frank Claessens, Kevin Verstrepen, Arnout Voet, Christine Helsen
- Discovery of a novel androgen receptor antagonist, MEL-6, with stereoselective activity and optimization of its metabolic stability.(2024)
Authors: Christine Helsen, Frank Claessens
Pages: 106476 - New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium(2024)
Authors: Frank Claessens
- Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants(2023)
Authors: Gert De Meerleer, Frank Claessens, Steven Joniau
Pages: 2065 - + - Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial(2023)
Authors: Karel David, Nick Narinx, Leen Antonio, Dirk Vanderschueren, Frank Claessens, Steven Joniau, Brigitte Decallonne
- A Multivalent Peptoid Conjugate Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-resistant Prostate Cancer.(2023)
Authors: Frank Claessens
Pages: 1166 - 1181 - Testosterone Restores Body Composition, Bone Mass, and Bone Strength Following Early Puberty Suppression in a Mouse Model Mimicking the Clinical Strategy in Trans Boys(2023)
Authors: Stefanie Doms, Sarah El Kharraz, Vera Maria Johanna Sommers, Karel David, Christa Maes, Leen Antonio, Brigitte Decallonne, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren
Pages: 1497 - 1508 - Double trouble for prostate cancer: synergistic action of AR blockade and PARPi in non-HRR mutated patients(2023)
Authors: Alexander Giesen, Loic Baekelandt, Herlinde Dumez, Wouter Everaerts, Frank Claessens, Steven Joniau
- Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry(2023)
Authors: Frank Claessens
Pages: 1200 - 1206