Researcher
Frans Gorus
- Research Expertise:
- Early biological markers of type 1 diabetes (susceptibility alleles, autoantibodies, beta cell secretion products) - Prediction of (complications of) diabetes and contribution to planning and launch of prevention trials - Epidemiology - General clinical chemistry www.bdronline.be
- Keywords:Medicine, General and logistic services
- Disciplines:Agricultural, veterinary and food sciences, Engineering and technology
- Users of research expertise:
- Early biological markers of type 1 diabetes (susceptibility alleles, autoantibodies, beta cell secretion products) - Prediction of (complications of) diabetes and contribution to planning and launch of prevention trials - Epidemiology - General clinical chemistry www.bdronline.be
Affiliations
- Diabetes Clinic (Department)
Member
From1 Oct 2019 → Today - Diabetes Pathology & Therapy (Research group)
Member
From1 Oct 2012 → Today - Clinical sciences (Department)
Member
From1 Oct 2023 → Today - Vriendenkring VUB (Office)
Member
From1 Oct 2017 → Today - Pathology/molecular and cellular medicine (Department)
Member
From1 Oct 2017 → 30 Sep 2023 - Clinical Biology (Department)
Member
From1 Oct 2015 → 30 Sep 2019 - Pathology/molecular and cellular medicine (Department)
Member
From1 Jan 2014 → 30 Sep 2022 - Pathologic Biochemistry and Physiology (Department)
Member
From1 Oct 1985 → 31 Dec 2013 - Pathological Anatomy (Department)
Member
From1 Jan 1981 → 30 Sep 1991 - Pathologic Biochemistry and Physiology (Department)
Member
From8 Oct 1975 → 31 Dec 1980
Projects
1 - 10 of 10
- Beta Cell Generation by Stem Cell-Derived Implants in DiabetesFrom1 Dec 2015 → 31 Aug 2022Funding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Influences of chronic hyperglycemia on development and properties of human beta cells, a study in implants generated by human induced pluripotent stem cells.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- SRP (Groeiers): Biomarkers for staging diabetes and guiding its prevention and treatmentFrom1 Mar 2014 → 28 Feb 2019Funding: BOF - Concerted Research Project from 1994
- Molecular and Cellular Basis for Beta Cell Therapy in DiabetesFrom1 Oct 2012 → 30 Sep 2013Funding: University - Project driven research
- Development and clinical validation of biological markers for beta cell destruction in vivoFrom1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Correlation between (changes in) functional beta cell mass and islet autoantibodies in (pre)type 1 diabetes with or without immune interventionFrom1 Oct 2011 → 30 Sep 2015Funding: FWO fellowships
- Link between residual beta cell function and glycemic variability in (pre)type 1 diabetesFrom1 Jan 2011 → 31 Dec 2014Funding: FWO research project (including WEAVE projects)
- BetaCellTherapy : Beta Cell Therapy in Diabetes.From1 Jan 2010 → 30 Jun 2015Funding: Health
- Prolongation: Centre for B-cell therapy in diabetesFrom1 Jan 2009 → 31 Dec 2013Funding: FWO scientific research network
- Differentiation of adult human pancreatic duct cells to functional beta cells through manipulation of gene expression and tissue culture conditionsFrom1 Jan 2008 → 31 Dec 2008Funding: FWO research grant KAN
Publications
1 - 10 of 57
- Baseline plasma proinsulin response to glucose for predicting therapeutic response to otelixizumab in recent-onset type 1 diabetes(2023)
Authors: Aster Desouter, Bart Keymeulen, Simke Demeester, Pieter De Pauw, Annelien Van Dalem, Bruno Lapauw, Christophe De Block, Pieter Gillard, Danny Pipeleers, F Gorus
- CTLA4, SH2B3 and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of type 1 diabetes patients(2023)
Authors: Julie Vandewalle, Aster Desouter, Bart J Van der Auwera, Sylvie Tenoutasse, Pieter Gillard, Christophe De Block, Bart Keymeulen, F Gorus, Mark Van de Casteele
Pages: 224-232 - Age-period-cohort modelling of type 1 diabetes incidence rates among children included in the EURODIAB 25-year follow-up study(2023)
Authors: J Svensson, E H Ibfelt, B Carstensen, A Neu, O Cinek, Torild Skrivarhaug, Birgit Rami-Merhar, Richard G Feltbower, C. Castell, D Konrad, et al.
Pages: 73-82 - Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives(2021)
Authors: Julie Vandewalle, Bart J Van der Auwera, Henna Amin, Erik Quartier, Aster Desouter, Sylvie Tenoutasse, Pieter Gillard, Christophe De Block, Bart Keymeulen, F Gorus, et al.
Pages: 2511-2516 - The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts(2021)
Authors: Geert A Martens, Geert M Stangé, Lorenzo Piemonti, Jasper Anckaert, Zhidong Ling, Daniel G Pipeleers, F Gorus, Pieter Mestdagh, Dieter De Smet, Jo Vandesompele, et al.
- Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens(2021)
Authors: Silke Smeets, Diedert Luc De Paep, Geert M Stangé, Katrijn Verhaeghen, Bart J Van der Auwera, Bart Keymeulen, Ilse Weets, Zhidong Ling, Pieter in 't Veld, F Gorus
Pages: 295-304 - A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes(2021)
Authors: Bart Keymeulen, André van Maurik, Dave Inman, João Oliveira, Rene McLaughlin, Rachel M Gittelman, Bart O Roep, Pieter Gillard, Robert Hilbrands, F Gorus, et al.
Pages: 313-324 - A composite immune signature parallels disease progression across T1D subjects(2019)
Authors: Cate Speake, Samuel O Skinner, Dror Berel, Elizabeth Whalen, Matthew J Dufort, William Chad Young, Jared M Odegard, Anne M Pesenacker, F Gorus, Eddie A James, et al.
- Immune checkpoint inhibitors and type 1 diabetes mellitus(2019)
Authors: Jeroen M.K. de Filette, Joeri Pen, Lore Decoster, Thomas Vissers, Bert Bravenboer, Bart J Van der Auwera, F Gorus, Bart O Roep, Sandrine Aspeslagh, B Neyns, et al.
Pages: 363-374 - Combined analysis of GAD65, miR-375, and unmethylated insulin DNA following islet transplantation in patients with T1D(2019)
Authors: Sarah Roels, Olivier Costa, Sarah A Tersey, Geert M Stangé, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Danny Pipeleers, et al.
Pages: 451-460