Researcher
Heleen Dewitte
- Keywords:cancer vaccination, microbubbles, tumor micro-environment, ultrasound, gene delivery, cancer immunotherapy, nanovaccine, Nanomedicine, drug delivery
- Disciplines:Adaptive immunology, Gene and molecular therapy, Vaccinology, Inflammation, Innate immunity, Cancer therapy, Drug discovery and development not elsewhere classified, Biopharmaceuticals, In vitro testing, Non-clinical studies, Nanobiotechnology, Medical nanotechnology, Cancer biology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2010 → 20 Dec 2020
Projects
1 - 6 of 6
- Fonds Catharina Weekers: "Expanding the immune army: Combatting multiple myeloma using a rational combination of Galsome nanovaccines and immune checkpoint inhibition"From1 Jul 2020 → 30 Jun 2023Funding: Foundations, funds and other with scientific goal
- Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Combatting multiple myeloma using Galsome immunotherapyFrom1 Oct 2019 → 20 Dec 2020Funding: BOF - postdoctoral mandates
- Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo.From1 Jan 2019 → 31 Dec 2019Funding: FWO research grant KAN
- Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)From1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
Publications
1 - 10 of 34
- Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine(2023)
Authors: Thomas Ertveldt, Sofie Meulewaeter, Yannick De Vlaeminck, Oscar Olarte, Katrijn Broos, Serge Van Calenbergh, Stephanie Bourgeois, Joke Deprez, Yves Heremans, Cleo Goyvaerts, et al.
Pages: 5483 - 5500 - Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium(2023)
Authors: Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer, et al.
Pages: 1341 - 1350 - Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model(2022)
Authors: Joke Deprez, Silke Roovers, Guillaume Lajoinie, Heleen Dewitte, Tine Decruy, Julie Coudenys, Benedicte Descamps, Christian Vanhove, Michel Versluis, Ine Lentacker
- The dawn of mRNA vaccines : the COVID-19 case(2021)
Authors: Rein Verbeke, Ine Lentacker, Heleen Dewitte
Pages: 511 - 520 - Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo(2021)
Authors: Jelter Van Hoeck, Thijs Van de Vyver, Aranit Harizaj, Glenn Goetgeluk, Pieterjan Merckx, Jing Liu, Mike Wels, Félix Sauvage, Herlinde De Keersmaecker, Christian Vanhove, et al.
- mRNA in cancer immunotherapy : beyond a source of antigen(2021)
Authors: Lien Van Hoecke, Rein Verbeke, Heleen Dewitte, Ine Lentacker, Karim Vermaelen, Karine Breckpot, Sandra Van Lint
- mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice(2020)
Authors: Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Sharon Van Nevel, Claus Bachert, Ine Lentacker
Pages: 777 - 787 - Ultrasound-responsive cavitation nuclei for therapy and drug delivery(2020)
Authors: Klazina Kooiman, Silke Roovers, Simone A. G. Langeveld, Robert T. Kleven, Heleen Dewitte, Meaghan A. O'Reilly, Jean-Michel Escoffre, Ayache Bouakaz, Martin D. Verweij, Kullervo Hynynen, et al.
Pages: 1296 - 1325 - Three decades of messenger RNA vaccine development(2019)
Authors: Rein Verbeke, Ine Lentacker, Stefaan De Smedt, Heleen Dewitte
- Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells(2019)
Authors: Rein Verbeke, Ine Lentacker, Karine Breckpot, Jonas Janssens, Serge Van Calenbergh, Stefaan De Smedt, Heleen Dewitte
Pages: 1655 - 1669
Patents
1 - 2 of 2