Researcher
Heleen Dewitte
- Keywords:cancer vaccination, microbubbles, tumor micro-environment, ultrasound, gene delivery, cancer immunotherapy, nanovaccine, Nanomedicine, drug delivery
- Disciplines:Adaptive immunology, Gene and molecular therapy, Vaccinology, Inflammation, Innate immunity, Cancer therapy, Drug discovery and development not elsewhere classified, Biopharmaceuticals, In vitro testing, Non-clinical studies, Nanobiotechnology, Medical nanotechnology, Cancer biology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2010 → 20 Dec 2020
Projects
1 - 6 of 6
- Fonds Catharina Weekers: "Expanding the immune army: Combatting multiple myeloma using a rational combination of Galsome nanovaccines and immune checkpoint inhibition"From1 Jul 2020 → 30 Jun 2023Funding: Foundations, funds and other with scientific goal
- Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Combatting multiple myeloma using Galsome immunotherapyFrom1 Oct 2019 → 20 Dec 2020Funding: BOF - postdoctoral mandates
- Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo.From1 Jan 2019 → 31 Dec 2019Funding: FWO research grant KAN
- Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)From1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
Publications
21 - 30 of 34
- Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon(2016)
Authors: Katrijn Broos, Kevin Vanderjeught, Janik Puttemans, Cleo Goyvaerts, Carlo Heirman, Heleen Dewitte, Rein Verbeke, Ine Lentacker, Kris Thielemans, Karine Breckpot
- Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger(2016)
Authors: Joke Devoldere, Heleen Dewitte, Katrien Remaut
Pages: 11 - 25 - Theranostic mRNA-loaded microbubbles in the lymphatics of dogs: implications for drug delivery(2015)
Authors: Heleen Dewitte, Katrien Vanderperren, Hendrik Haers, Emmelie Stock, Ine Lentacker
Pages: 97 - 109 - Combinatorial strategies for the induction of immunogenic cell death(2015)
Authors: Lucillia Bezu, Ligia C Gomes-da-Silva, Heleen Dewitte, Karine Breckpot, Jitka Fucikova, Radek Spisek, Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer
- Microbubbles as magic bullets in cancer immunotherapy(2015)
Authors: Heleen Dewitte, Katrien Vanderperren, Hendrik Haers, Emmelie Stock, Karine Breckpot, Ine Lentacker
Pages: 34 - 36 - Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination(2015)
Authors: Rein Verbeke, Heleen Dewitte, Ine Lentacker
Number of pages: 1 - The ReNAissanCe of mRNA-based cancer therapy(2015)
Authors: Dries Renmans, Katrijn Broos, Heleen Dewitte, Ine Lentacker, Carlo Heirman, Karine Breckpot, Kris Thielemans
Pages: 235 - 251 - Design and evaluation of immunotherapeutic imaging for cancer vaccination(2015)
Authors: Heleen Dewitte
- Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment(2014)
Authors: Heleen Dewitte, Rein Verbeke, Karine Breckpot, Ine Lentacker
Pages: 743 - 758 - Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro(2014)
Authors: Heleen Dewitte, Rein Verbeke, Karine Breckpot, Claude Libert, Ine Lentacker
Pages: 138 - 146
Patents
1 - 2 of 2