Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
31 - 40 of 547
- Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes(2017)
Authors: Els Vanstreels, Wim Dehaen, Sandra Liekens, Jan Balzarini
Pages: 219 - 235 - A multitarget approach toward the development of 8-substituted purines for photoprotection and prevention of UV-related damage(2017)
Authors: Jan Balzarini, Sandra Liekens
Pages: 760 - 769 - 6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins(2017)
Authors: Jan Balzarini, Erik De Clercq
Pages: 1611 - 1615 - Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid(2017)
Authors: Liang Sun, Jan Balzarini, Sam Noppen, Sandra Liekens, Dominique Schols, Johan Neyts, Pieter Leyssen, Carmen Mirabelli
Pages: 32 - 40 - Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products (vol 15, pg 1130, 2017)(2017)
Authors: Hari K Akula, Hariprasad Kokatla, Graciela Andrei, Robert Snoeck, Dominique Schols, Jan Balzarini, Lijia Yang, Mahesh K Lakshman
Pages: 1268 - 1268 - Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products(2017)
Authors: Graciela Andrei, Robert Snoeck, Dominique Schols, Jan Balzarini
Pages: 1130 - 1139 - ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites(2016)
Authors: Jan Balzarini
Pages: 5618 - 5623 - Novel isoxazolidine analogues of homonucleosides and homonucleotides(2016)
Authors: Jan Balzarini, Graciela Andrei, Dominique Schols, Robert Snoeck
Pages: 8294 - 8308 - Niacin esters of chalcones with tumor-selective properties(2016)
Authors: Jan Balzarini, Erik De Clercq
Pages: 1451 - 1456 - Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis Binding of Foscarnet (vol 11, pg 2158, 2016)(2016)
Authors: Kalyan Das, Jan Balzarini, Matthew T Miller, Anita R Maguire, Jeffrey J DeStefano, Eddy Arnold
Pages: 3226 - 3226
Patents
1 - 10 of 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)